May 29, 2021

Proteasome inhibition for treatment of leishmaniasis, Chagas disease and sleeping sickness | Nature

A selective inhibitor of the kinetoplastid proteasome (GNF6702) is identified that is highly efficacious in vivo, clearing the parasites that cause leishmaniasis, Chagas disease and sleeping sickness from mice, highlighting the possibility of developing a single class of drugs for these neglected diseases.

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