Aug 01, 2019

Exome sequencing of hepatocellular carcinomas identifies new mutational signatures and potential therapeutic targets | Nature Genetics

Jessica Zucman-Rossi and colleagues report exome sequences of 243 hepatocellular carcinomas. They identify mutational signatures associated with specific risk factors such as alcohol, tobacco and aflatoxin B1 and find genetic alterations potentially targetable by FDA-approved drugs in 28% of the tumors.

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