Dec 17, 2019

Prediction of LDL cholesterol response to statin using transcriptomic and genetic variation | Genome Biology | Full Text

Statins are widely prescribed for lowering LDL-cholesterol (LDLC) levels and risk of cardiovascular disease. There is, however, substantial inter-individual variation in the magnitude of statin-induced LDLC reduction. To date, analysis of individual DNA sequence variants has explained only a small proportion of this variability. The present study was aimed at assessing whether transcriptomic...

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