Mar 28, 2019

Axonal Endoplasmic Reticulum Ca2+ Content Controls Release Probability in CNS Nerve Terminals: Neuron

de Juan-Sanz et al. have developed novel, genetically encoded ER-targeted Ca2+ sensors to study ER Ca2+ fluxes in nerve terminals during electrical activity. Using these tools they demonstrate that ER Ca2+ content is critical for synaptic function and show that ER Ca2+ drives a STIM1-based feedback loop that controls Ca2+ influx and exocytosis.

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